Expert Interviews: Physico-Chemical Characterization
Physico-chemical characterisation of nanoparticles, small and large (bio)molecules and nano-formulations is essential to understand the behaviour of a nanomedicine and provides guidance for the process of design, development, control and safety assessment.
In the case of nanomedicines, an adequate and complete characterisation is inherently complex because of the heterogeneity and structural complexity which usually cannot be measured and/or analysed with traditional analytical techniques.
PHOENIX-OITB brings together a wide palette of analytical techniques that covers all the physico-chemical parameters that need to be determined.
Moreover, the knowledge on physico-chemical characterisation that the service providers have acquired allows them to potentially develop new analytical methods, if needed, tailored to the specific nanomedicine/nanomaterial to be analysed.
Finally, the PHOENIX-OITB has SOPs for most of the techniques and assays they provide, and counts with some specific techniques to determine parameters (e.g. distinction between free from encapsulated API) that cannot be found easily.
Jesus M. de la Fuente of the Spanish National Research Council (CSIC) describes the phys-chem characterization services of the PHOENIX-OITB and their benefits for customers, as well as CSIC’s experiences in demo cases and Open Call projects.
To access physico-chemical characterization services through a Single Entry Point, visit PHOENIX SEP.
